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- bs-7377R-APC-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-7377R-APC-Cy7 |
| 英文名称 | NCK adaptor protein 1/2 Rabbit pAb, APC-Cy7 conjugated |
| 中文名称 | APC-Cy7标记的NCK衔接蛋白1/2抗体 |
| 英文别名 | Nck 1/2; NCK adaptor protein 1+2GRB4; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK adaptor protein 2; NCK tyrosine kinase; NCKalpha; NCKbeta; NCK1_HUMAN; NCK12_HUMAN; non catalytic region of tyrosine kinase; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK alpha; SH2/SH3 adaptor protein NCK beta |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NCK adaptor protein 1/2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors Cancer > Oncoproteins/suppressors > Oncoproteins Cancer > Signal transduction Cell Biology > Cell Cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1. |
| 亚细胞定位 | Cytoplasm. Endoplasmic reticulum. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated. |
| 相似性 | Contains 1 SH2 domain. Contains 3 SH3 domains. |
| 功能 | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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NCK adaptor protein 1/2 Rabbit pAb, APC-Cy7 conjugated(bs-7377R-APC-Cy7)-100ul
￥2980
