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- bs-7377R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-7377R-AP |
| 英文名称 | NCK adaptor protein 1/2 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的NCK衔接蛋白1/2抗体 |
| 英文别名 | Nck 1/2; NCK adaptor protein 1+2GRB4; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK adaptor protein 2; NCK tyrosine kinase; NCKalpha; NCKbeta; NCK1_HUMAN; NCK12_HUMAN; non catalytic region of tyrosine kinase; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK alpha; SH2/SH3 adaptor protein NCK beta |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ELISA=1:500-5000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NCK adaptor protein 1/2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors Cancer > Oncoproteins/suppressors > Oncoproteins Cancer > Signal transduction Cell Biology > Cell Cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1. |
| 亚细胞定位 | Cytoplasm. Endoplasmic reticulum. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated. |
| 相似性 | Contains 1 SH2 domain. Contains 3 SH3 domains. |
| 功能 | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ELISA} | {1:500-5000} |
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文献和实验Rapid Inactivation of Proteins by Knocksideways
Willox, A.K. and Royle, S.J. 2012. Stonin 2 is a major adaptor protein for clathrin‐mediated synaptic vesicle retrieval. Curr. Biol. 22:1435‐1439. Wu, X., Zhao, X., Puertollano
结构域，能相互缠绕形成跨SNAREs复合体（trans-SNAREs complexes），将运输小泡的膜与靶膜拉在一起，实现运输小泡特异性停泊和融合。 在神经细胞中SNAREs负责突触小泡的停泊和融合。 破伤风毒素和肉毒素等细菌分泌的神经性毒素实际上是一类特殊的蛋白酶，能够选择性地降解SNAREs，从而阻断神经传导。 病毒融合蛋白的工作原理与SNAREs相似，介导病毒与宿主质膜的融合。 NSF催化SNAREs的分离，它能利用ATP作为能量通过插入几个适配蛋白（adaptor protein
TRAF‐Mediated TNFR‐Family Signaling
differentiation factor osteoprotegerin‐ligand is essential for mammary gland development. Cell 103:41‐50. Feng, X., Gaeta, M.L., Madge, L.A., Yang, J.H., Bradley, J.R., and Pober, J.S
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