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- bs-21419R-IRDye800CW
- 2025年09月30日
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100ul
| 产品编号 | bs-21419R-IRDye800CW |
| 英文名称 | Klrb1 Rabbit pAb, IRDye 800CW conjugated |
| 中文名称 | IRDye 800CW标记的NKR-P1G抗体 |
| 英文别名 | Killer cell lectin-like receptor subfamily B member 1; Killer cell lectin-like receptor subfamily B member 1G; Natural killer cell surface protein NKR-P1G; Natural killer lectin-like receptor 1E; Gm4696; Klrb1d; Klrb1g; Klrb6; Nkrp1g; Ly55; Ly-55; NKR-P1G; Nkrp-1e; 4930431A04Rik; KLRB1_MOUSE; KLRB1_RAT; CD161c(mouse); CD161a(rat); |
| 产品应用 | WB=1000-10000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from rat Klrb1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Contains 1 C-type lectin domain. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| 翻译后修饰 | N-glycosylated. Contains sialic acid residues. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1000-10000} |
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Klrb1 Rabbit pAb, IRDye 800CW conjugated(bs-21419R-IRDye800CW)-100ul
￥2980
