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- bsm-41327M-Cy7
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100ul
| 产品编号 | bsm-41327M-Cy7 |
| 英文名称 | ZO-1 Mouse mAb, Cy7 conjugated |
| 中文名称 | Cy7标记的胞质紧密粘连蛋白1/闭锁小带蛋白1单克隆抗体 |
| 英文别名 | ZO1_HUMAN; Tight junction protein ZO-1; TJP1; ZO1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1; ZO1 tight junction protein; |
| 产品应用 | ICC/IF=1:50-200, Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human ZO-1 protein |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Tags & Cell Markers > Subcellular Markers > Plasma Membrane |
| 亚基 | Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and MYZAP. Interacts (via PDZ domain) with GJA1. |
| 亚细胞定位 | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells. |
| 组织特异性 | The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. |
| 翻译后修饰 | Phosphorylated. Dephosphorylated by PTPRJ. |
| 相似性 | Belongs to the MAGUK family._x000D_
Contains 1 guanylate kinase-like domain._x000D_ Contains 3 PDZ (DHR) domains._x000D_ Contains 1 SH3 domain._x000D_ Contains 1 ZU5 domain. |
| 功能 | The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {Flow-Cyt} | {1μg/Test} |
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ZO-1 Mouse mAb, Cy7 conjugated(bsm-41327M-Cy7)-100ul
￥2980
