PR3 Mouse mAb, BF350 conjugated(bsm-43164M-BF350)-100ul

PR3 Mouse mAb, BF350 conjugate

d(bsm-43164M-BF350)-100ul
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  • ￥2980
  • Bioss已认证
  • bsm-43164M-BF350
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bsm-43164M-BF350
    英文名称PR3 Mouse mAb, BF350 conjugated
    中文名称BF350标记的白细胞蛋白酶3单克隆抗体
    英文别名ACPA; AGP 7; AGP7; AGP7 serine proteinase; Azurophil Granule Protein 7; C ANCA antigen; C-ANCA antigen; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT WEGENER AUTOANTIGEN; Myeloblastin; Neutrophil proteinase 4; NP 4; NP-4; NP4; P29; PR 3; PR-3; Proteinase3; PRTN 3; Prtn3; PRTN3_HUMAN; Serine proteinase neutrophil Wegener granulomatosis autoantigen; Wegener autoantigen.
    产品应用ICC/IF=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Mouse
    免疫原Recombinant human PR3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Monoclonal
    储存液0.01M PBS(pH7.4)
    研究领域

    Signal Transduction > Cytoskeleton / ECM > Basal Lamina

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Collagen

    相似性Belongs to the peptidase S1 family. Elastase subfamily.
    _x000D_ Contains 1 peptidase S1 domain.
    功能Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
    保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    背景资料The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}

     

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