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| 产品编号 | bs-42054R-AP |
| 英文名称 | CD36 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的CD36抗体 |
| 英文别名 | Platelet glycoprotein 4; PAS-4; Platelet glycoprotein IV; Glycoprotein IIIb; GPIV; GPIIIB; GP3B; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor; CD_antigen: GP4; CD36_HUMAN. |
| 产品应用 | IHC-P=1:100-500, WB=1000-10000, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | Recombinant mouse CD36 protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Atherosclerosis > Lipid transport Cardiovascular > Blood > Platelets Immunology > Cell Type Markers > CD > Platelets Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Metabolism > Types of disease > Heart disease Microbiology > Protein > Human Protein > Defensin Stem Cells > Endothelial Progenitors > Endothelial Markers Stem Cells > Hematopoietic Progenitors > Hematopoietic Stem Cells > Human Lineage Negative |
| 亚基 | Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes. |
| 翻译后修饰 | N-glycosylated and O-glycosylated with a ratio of 2:1. |
| 相似性 | Belongs to the CD36 family. |
| 功能 | Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {WB} | {1000-10000} |
| {IHC-F} | {1:100-500} |
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文献和实验乳腺及人类乳腺癌组织在三苯氧胺治疗前，治疗中的mRNA进行对比［16］，分离到一个202 bp的cDNA(AP5-1)在正常及治疗前表达，而治疗后缺失。AP5-1与CD36基因有99%同源性，而后者为细胞外基质蛋白凝血酶敏感蛋白(thrombospondin-1)的受体。已知其参与肿瘤细胞的血行转移、浸润及血管形成。可见三苯氧胺通过使其受体下调而发挥抗肿瘤作用。宫颈细胞的癌变是多因素多步骤的过程。HPV感染是主要原因，但病毒感染者癌变的长潜伏期及少于50%的癌变率说明癌变需要其他因素共同作用，如吸烟［
Developing Genetically Engineered Mouse Models to Study Tumor Suppression
Literature Cited Armstrong, J.F., Kaufman, M.H., Harrison, D.J., and Clarke, A.R. 1995. High‐frequency developmental abnormalities in p53‐deficient mice. Curr
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