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- bs-10467R-PerCP
- 2025年09月30日
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100ul
| 产品编号 | bs-10467R-PerCP |
| 英文名称 | DRAK2 Rabbit pAb, PerCP conjugated |
| 中文名称 | PerCP标记的DAP凋亡诱导蛋白激酶2抗体 |
| 英文别名 | DAP kinase related apoptosis inducing protein; DAP kinase related apoptosis inducing protein kinase 2; Death associated protein kinase related 2; DRAK 2; Serine/threonine kinase 17b(apoptosis inducing); Serine/threonine kinase 17b; Serine/threonine protein kinase 17B; STK17B; ST17B_HUMAN. |
| 产品应用 | ICC/IF=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DRAK2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus. |
| 亚细胞定位 | Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=Colocalizes with STK17B at the plasma membrane. |
| 组织特异性 | Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney. |
| 翻译后修饰 | Autophosphorylated. |
| 相似性 | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily._x000D_ Contains 1 protein kinase domain. |
| 功能 | Acts as a positive regulator of apoptosis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
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DRAK2 Rabbit pAb, PerCP conjugated(bs-10467R-PerCP)-100ul
￥2980
