EPN1 | Epsin-1 Rabbit pAb, APC-Cy7 conj.(bs-13101R-APC-Cy7)-100ul产品图

EPN1 | Epsin-1 Rabbit pAb, APC

-Cy7 conj.(bs-13101R-APC-Cy7)-100ul
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  • bs-13101R-APC-Cy7
  • 2026年10月17日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-13101R-APC-Cy7
    英文名称Epsin 1 Rabbit pAb, APC-Cy7 conjugated
    中文名称APC-Cy7标记的内吞作用辅助蛋白EPN1抗体
    英文别名EH domain binding mitotic phosphoprotein; EPN1; EPN 1; EPN-1; EPS 15 interacting protein 1; EPS-15-interacting protein 1; Epsin 1; EPN1_HUMAN.
    产品应用ICC/IF=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Epsin 1/EPN1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Adapters > Cytoplasmic

    Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation

    亚基Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1. Binds ubiquitinated proteins (By similarity). Binds REPS2, EPS15, AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. [SUBCELLULAR LOCATION]
    亚细胞定位Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
    翻译后修饰Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
    Ubiquitinated (By similarity).
    相似性Belongs to the epsin family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 3 UIM (ubiquitin-interacting motif) repeats.
    功能Epsin 1 is a cytosolic adaptor protein and interacting partner for the EH domain containing region of Eps15. It is involved in the regulation of clathrin mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15. Epsin 1 is a cargo specific adaptor for influenza virus entry through the clathrin mediated pathway. In addition to being a clathrin interacting protiein, Epsin 1 is also an ubiquitin, and phospholipid interacting protein. It also may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料Epsin 1 is an endocytic accessory protein, with significant similarity to the Xenopus mitotic phosphoprotein MP90. Epsin 1 interacts with Eps15 (the ?subunit of the Clathrin adaptor AP2), Clathrin and other accessory proteins. The mitotic phosphorylation of these proteins may be one of the mechanisms by which the invagination of Clathrin-coated pits is blocked in mitosis. Both Epsin and Eps15, like other cytosolic components of the synaptic vesicle endo-cytic machinery, undergo constitutive phosphorylation and depolarization-dependent dephosphorylation in nerve terminals. Epsin 1 also contributes to the mechanism of Clathrin-vesicle-dependent endocytosis. The human Epsin 1 protein contains an Epsin N-terminal homology (ENTH) region and a single Clathrin-binding (LVDLD) motif. Epsin 1 localizes to the leading edge of a vesicular coated pit where the membrane is being actively bent.

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}

     

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