PIRH2 Rabbit pAb, BF350 conjugated(bs-4895R-BF350)-100ul

PIRH2 Rabbit pAb, BF350 conjug

ated(bs-4895R-BF350)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-4895R-BF350
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-4895R-BF350
    英文名称PIRH2 Rabbit pAb, BF350 conjugated
    中文名称BF350标记的泛素连接酶抗体
    英文别名Androgen receptor N terminal interacting protein; Androgen receptor N-terminal-interacting protein; ARNIP; CH-rich-interacting match with PLAG1; CHIMP; E3 ubiquitin-protein ligase Pirh2; hARNIP; hPirh2; p53 induced protein with a RING H2 domain; p53-induced RING-H2 protein; PIRH2E; PIRH2F; PRO1996; RCHY1; Ring finger and CHY zinc finger domain containing 1 E3 ubiquitin protein ligase; RING finger and CHY zinc finger domain-containing protein 1; RING finger protein 199; RNF199; ZFP 363; Zinc finger protein 363; ZN363_HUMAN.
    产品应用Flow-Cyt=2ug/Test, ICC/IF=1:50-200, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PIRH2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell cycle > Cell cycle inhibitors > p53 pathway

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin

    亚基Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.
    亚细胞定位Nucleus. Nucleus speckle. Cytoplasm.
    组织特异性Detected in testis, liver, kidney and heart.
    翻译后修饰Subject to ubiquitination and proteasomal degradation.
    相似性Contains 1 CHY-type zinc finger._x000D_
    Contains 1 CTCHY-type zinc finger._x000D_
    Contains 1 RING-type zinc finger.
    功能Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Contributes to the regulation of CDKN1B and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料PirH2 has ubiquitin-protein ligase activity. It binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53 (referenced from entrez gene).[SUBUNIT] Monomer and homodimer. [SUBCELLULAR LOCATION] Nucleus. Nucleus speckle. Cytoplasm.

     

    应用推荐稀释比例
    {Flow-Cyt}{2ug/Test}
    {ICC/IF}{1:50-200}
    {IF}{1:100-500}

     

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