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- bs-15428R-BF405
- 2025年09月30日
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100ul
| 产品编号 | bs-15428R-BF405 |
| 英文名称 | HCP1 Rabbit pAb, BF405 conjugated |
| 中文名称 | BF405标记的血红素转运蛋白1抗体 |
| 英文别名 | G21; HCP 1; Heme Carrier Protein 1; MGC9564; PCFT; PCFT/HCP1; PCFT_HUMAN; PDE7A; Proton coupled folate transporter; Proton-coupled folate transporter; SLC46A1; Solute carrier family 46 member 1; |
| 产品应用 | Flow-Cyt=2ug/Test, ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HCP1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Apical cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. |
| 组织特异性 | Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. |
| 相似性 | Belongs to the major facilitator superfamily. SLC46A family. |
| 功能 | Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2ug/Test} |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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HCP1 Rabbit pAb, BF405 conjugated(bs-15428R-BF405)-100ul
￥2980
