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- bs-10283R-FITC
- 2025年09月30日
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100ul
| 产品编号 | bs-10283R-FITC |
| 英文名称 | PHB2 Rabbit pAb, FITC conjugated |
| 中文名称 | FITC标记的B细胞受体相关蛋白抗体 |
| 英文别名 | PHB2_HUMAN; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity; BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141; |
| 产品应用 | ICC/IF=1:100-500, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PHB2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Estrogen Signal Transduction > Growth Factors/Hormones > Hormones Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Estrogen |
| 亚基 | Interacts with PHB, ESR1, HDAC1 and HDAC5. Interacts with ZNF703. |
| 亚细胞定位 | Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear. |
| 相似性 | Belongs to the prohibitin family. |
| 功能 | Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1ug/test} |
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PHB2 Rabbit pAb, FITC conjugated(bs-10283R-FITC)-100ul
￥2980
