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- bs-23549R-BF555
- 2025年09月30日
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100ul
| 产品编号 | bs-23549R-BF555 |
| 英文名称 | Neutrophil Elastase Rabbit pAb, BF555 conjugated |
| 中文名称 | BF555标记的中性粒细胞弹性蛋白酶ELANE抗体 |
| 英文别名 | Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte Elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN Elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Neutrophil Elastase |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix Immunology > Innate Immunity > Complement > Regulatory Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > NK Cells Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Adhesion molecules ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Angiogenic factors ELISA kits Microbiology > Protein > Human Protein > Defensin Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Elastin Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚基 | Interacts with NOTCH2NL. |
| 组织特异性 | Bone marrow cells. |
| 相似性 | Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain. |
| 功能 | Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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