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- Bioss
- bs-12365R-BF647
- 2025年09月30日
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100ul
| 产品编号 | bs-12365R-BF647 |
| 英文名称 | SIX2 Rabbit pAb, BF647 conjugated |
| 中文名称 | BF647标记的转录因子同源框蛋白SIX2抗体 |
| 英文别名 | Homeobox protein SIX2; OTTHUMP00000201649; Sine oculis homeobox(Drosophila) homolog 2; Sine oculis homeobox homolog 2; Sine oculis homeobox homolog 2(Drosophila); SIX homeobox 2; Six2; SIX2_HUMAN. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SIX2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Organogenesis > Excretory system development > Kidney development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Stem Cells > Mesenchymal Stem Cells > Chondrogenesis |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Strongly expressed in skeletal muscle. |
| 相似性 | Belongs to the SIX/Sine oculis homeobox family. _x000D_ Contains 1 homeobox DNA-binding domain. |
| 功能 | May be involved in limb tendon and ligament development. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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SIX2 Rabbit pAb, BF647 conjugated(bs-12365R-BF647)-100ul
￥2980
