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- bs-2894R-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-2894R-Cy7 |
| 英文名称 | HDAC11 Rabbit pAb, Cy7 conjugated |
| 中文名称 | Cy7标记的组蛋白去乙酰化酶11抗体 |
| 英文别名 | HD 11; HD11; HDAC 11; Histone deacetylase 11; FLJ22237; HDA11_HUMAN. |
| 产品应用 | Flow-Cyt=2ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HDAC11 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class I Stem Cells > Signaling Pathways > Wnt > HDACs |
| 亚基 | Interacts with HDAC6. |
| 亚细胞定位 | Nucleus. Note=Predominantly nuclear._x000D_ |
| 组织特异性 | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. |
| 相似性 | Belongs to the histone deacetylase family. |
| 功能 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Histone deacetylases (HDAC) are a family of 11 enzymes that are involved in the regulation of gene activation and silencing by regulating chromatin structure. HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Deacetylation of histones is associated with the condensation of chromatin to a compact structure (heterochromatin) in which the genes are silenced. Each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDACs are known to be associated with a number of well characterized cellular oncogenes and tumour- suppressor genes and inhibitors of HDACs induce growth arrest, differentiation or apoptosis of cancer cells in vitro and in vivo. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2ug/Test} |
| {IF} | {1:100-500} |
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HDAC11 Rabbit pAb, Cy7 conjugated(bs-2894R-Cy7)-100ul
￥2980
