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- bs-5948R-PE-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-5948R-PE-Cy5.5 |
| 英文名称 | CIP2A/p90 Autoantigen Rabbit pAb, PE-Cy5.5 conjugated |
| 中文名称 | PE-Cy5.5标记的蛋白磷酸酶PP2A癌抑制蛋白抗体 |
| 英文别名 | p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen. |
| 产品应用 | ICC/IF=1:100-500, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human p90 Autoantigen |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins Cancer > Tumor biomarkers |
| 亚基 | Interacts with MYC. |
| 亚细胞定位 | Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. |
| 组织特异性 | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1ug/test} |
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CIP2A/p90 Autoantigen Rabbit pAb, PE-Cy5.5 conjugated(bs-5948R-PE-Cy5.5)-100ul
￥2980
