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- bs-3523R-Cy5.5
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100ul
| 产品编号 | bs-3523R-Cy5.5 |
| 英文名称 | PBK Rabbit pAb, Cy5.5 conjugated |
| 中文名称 | Cy5.5标记的PDZ连接激酶/T-LAK细胞源蛋白激酶抗体 |
| 英文别名 | TOPK; Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine activated killer T cell originated protein kinase; MAPKK like protein kinase; PDZ-binding-kinase/T-LAK cell-originated protein kinase; Nori 3; Nori3; PDZ binding kinase; Serine/threonine protein kinase; Spermatogenesis related protein kinase; SPK; T LAK cell originated protein kinase; TOPK. |
| 产品应用 | ICC/IF=1:100-500, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PBK |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors > p53 pathway Cell Biology > Cell Cycle > Cell Cycle Inhibitors > p53 Cell Biology > Cell Cycle > Cell Division > Cytokinesis Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > p53 Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway |
| 亚基 | Interacts with DLG1 and TP53. |
| 组织特异性 | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
| 翻译后修饰 | Phosphorylated; in a cell-cycle dependent manner at mitosis. |
| 相似性 | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily._x000D_
Contains 1 protein kinase domain. |
| 功能 | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1ug/test} |
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PBK Rabbit pAb, Cy5.5 conjugated(bs-3523R-Cy5.5)-100ul
￥2980
