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- Bioss
- bs-6143R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-6143R-Bio |
| 英文名称 | PIG3 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的p53诱导蛋白3抗体 |
| 英文别名 | p53 induced gene 3 protein; p53-induced gene 3 protein; Putative quinone oxidoreductase; quinone oxidoreductase homolog; TP53I3; tumor protein p53 inducible protein 3; Tumor protein p53-inducible protein 3; QORX_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PIG3/TP53I3 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway Cell Biology > Apoptosis > Intracellular > p53 Pathway Cell Biology > Other Antibodies > Oxidative Stress Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > p53 Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress |
| 亚基 | Homodimer. |
| 相似性 | Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. |
| 功能 | May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene (from EntrezGene). |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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PIG3 Rabbit pAb, Biotin conjugated(bs-6143R-Bio)-100ul
￥2980
