phospho-PTPN11 (Tyr580) Rabbit pAb, APC conjugated(bs-3405R-APC)-100ul

phospho-PTPN11 (Tyr580) Rabbit

pAb, APC conjugated(bs-3405R-APC)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-3405R-APC
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-3405R-APC
    英文名称phospho-PTPN11 (Tyr580) Rabbit pAb, APC conjugated
    中文名称APC标记的磷酸化蛋白酪氨酸磷酸酶2抗体
    英文别名PTN11_HUMAN; Tyrosine-protein phosphatase non-receptor type 11; PTP2C; SHPTP2; EC:3.1.3.48; Protein-tyrosine phosphatase 1D(PTP-1D); Protein-tyrosine phosphatase 2C(PTP-2C); SH-PTP2(SHP-2; Shp2); SH-PTP3; protein tyrosine phosphatase non-receptor type 11; CFC; NS1; JMML; BPTP3; PTP2C; METCDS;
    产品应用ICC/IF=1:100-500, IF=1:100-500, Flow-Cyt=1ug/test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human PTPN11/SHP2 around the phosphorylation site of Tyr580
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Sensory System > Auditory system

    Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases

    亚基Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and IN‌‌PP5D/SHIP1. Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity.
    亚细胞定位Cytoplasm.
    组织特异性Widely expressed, with highest levels in heart, brain, and skeletal muscle.
    翻译后修饰Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
    相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily._x000D_
    Contains 2 SH2 domains._x000D_
    Contains 1 tyrosine-protein phosphatase domain.
    功能Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}
    {Flow-Cyt}{1ug/test}

     

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