Phosphor-PPP3CA (Ser469) Rabbit pAb, PE-Cy5 conjugated(bs-10343R-PE-Cy5)-100ul

Phosphor-PPP3CA (Ser469) Rabbi

t pAb, PE-Cy5 conjugated(bs-10343R-PE-Cy5)-100ul
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  • ￥2980
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  • bs-10343R-PE-Cy5
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-10343R-PE-Cy5
    英文名称Phosphor-PPP3CA (Ser469) Rabbit pAb, PE-Cy5 conjugated
    中文名称PE-Cy5标记的磷酸化钙调磷酸酶A/钙依赖磷酸酶A抗体
    英文别名PPP3CA(phosphor S469); PPP3CA(phosphor Ser469); Calcineurin A alpha; CalcineurinA; Calcineurin-A; Calcineurin A; Calmodulin dependent calcineurin A subunit alpha isoform; CALN; CALNA 1; CALNA; CALNA1; CAM PRP catalytic subunit; CCN 1; CCN1; CNA 1; CNA; CNA1; PPP2B; Protein phosphatase 3(formerly 2B) catalytic subunit alpha isoform; Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform; PP2BA_HUMAN; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform; protein phosphatase 2B, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.
    产品应用ICC/IF=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human PPP3CA around the phosphorylation site of Ser469
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Immunology > Adaptive Immunity > B Cells > Non-CD

    Signal Transduction > Protein Phosphorylation > Ser / Thr Phosphatases

    Signal Transduction > Signaling Pathway > Calcium Signaling > Calmodulin Pathway

    亚基Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.
    亚细胞定位Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.
    组织特异性Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.
    相似性Belongs to the PPP phosphatase family. PP-2B subfamily.
    功能Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2, 61 and 59 kDa, respectively).

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}
    {IF}{1:100-500}

     

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