HSPG2 Rabbit pAb, HRP conjugated(bs-42231R-HRP)-100ul

HSPG2 Rabbit pAb, HRP conjugat

ed(bs-42231R-HRP)-100ul
收藏
  • ￥2980
  • Bioss已认证
  • bs-42231R-HRP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
avatar
北京博奥森生物技术有限公司
品牌商
9 年钻石会员

  • 企业认证

    点击 QQ 联系

    • 相关产品推荐更多 >

    万千商家帮你免费找货

    0 人在求购买到急需产品
    • 详细信息
    • 技术资料
    • 应用范围：

      产品信息以Bioss网站为准

    • 规格：

      100ul

    产品编号bs-42231R-HRP
    英文名称HSPG2 Rabbit pAb, HRP conjugated
    中文名称HRP标记的硫酸乙酰肝素蛋白多糖2抗体
    英文别名Heparan Sulphate Proteoglycan; Perlecan; Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin(domain V region); Heparan Sulfate Proteoglycan; Heparan sulfate proteoglycan of basement membrane; HSPG 2; HSPG; Hspg2; LG3 peptide; Perlecan; PLC antibody Schwartz Jampel syndrome 1(chondrodystrophic myotonia); SJA antibody SJS antibody SJS1 antibody.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原Recombinant human HSPG2 protein
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins

    Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix

    Cardiovascular > Angiogenesis > Adhesion / ECM > Integrins

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

    Metabolism > Types of disease > Cancer

    Signal Transduction > Cytoskeleton / ECM > Basal Lamina

    Signal Transduction > Cytoskeleton / ECM > HSPGs

    亚细胞定位Secreted, extracellular space, extracellular matrix, basement membrane.
    组织特异性Found in the basement membranes.
    翻译后修饰Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide._x000D_
    N- and O-glycosylated; contains three heparan sulfate chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation.
    相似性Contains 4 EGF-like domains.
    Contains 22 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 11 laminin EGF-like domains.
    Contains 3 laminin G-like domains.
    Contains 3 laminin IV type A domains.
    Contains 4 LDL-receptor class A domains.
    Contains 1 SEA domain.
    功能Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.
    _x000D_ [FUNCTION] Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.
    _x000D_
    The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans(heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    Oxytocin R Antibody HRP Conjugated
    询价
    南京赛戈巍生物科技有限公司
    2025年05月23日询价
    R1208-2·HRP Conjugated Anti-Myc Tag Antibody
    ￥1200
    杭州华安生物技术有限公司
    2025年07月09日询价
    Oxytocin R Antibody HRP Conjugated抗体，orb1543032，Biorbyt
    ￥8316
    武汉博欧特生物科技有限公司
    2025年07月15日询价
    Ankyrin R Antibody: HRP
    ￥4233.60
    深圳欣博盛生物科技有限公司
    2025年03月31日询价
    Ankyrin R 抗体: HRP
    询价
    StressMarq Biosciences Inc.
    2025年06月01日询价
    HSPG2 Rabbit pAb, HRP conjugated(bs-42231R-HRP)-100ul
    ￥2980