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- bs-1015R-PE-Cy5
- 2025年09月30日
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100ul
| 产品编号 | bs-1015R-PE-Cy5 |
| 英文名称 | BRMS1 Rabbit pAb, PE-Cy5 conjugated |
| 中文名称 | PE-Cy5标记的乳腺癌转移抑制基因1抗体 |
| 英文别名 | AV003220; AW554636; Breast cancer metastasis suppressor 1; BRMS-1; BRMS1; BRMS 1; DKFZp564A063; MGC95128; BRMS1_HUMAN. |
| 产品应用 | ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human BRMS-1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors |
| 亚基 | Belongs to the BRMS1 family. |
| 亚细胞定位 | Nucleus. Cytoplasm. Predominantly nuclear. |
| 组织特异性 | Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. |
| 翻译后修饰 | Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. |
| 相似性 | Belongs to the BRMS1 family._x000D_ |
| 功能 | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-ⅹB activity. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
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BRMS1 Rabbit pAb, PE-Cy5 conjugated(bs-1015R-PE-Cy5)-100ul
￥2980
