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- bs-25756R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-25756R-HRP |
| 英文名称 | Myosin VIIa Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的肌球蛋白7a/常染色体隐性耳聋蛋白2抗体 |
| 英文别名 | Deafness autosomal dominant 11; Deafness autosomal recessive 2; DFNA11; DFNB 2; DFNB2; Myo7a; Myosin 7a; Myosin VIIa; MYU7A; NSRD 2; NSRD2; Ush 1B; Ush1b; Usher syndrome 1B. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Myosin VIIa |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Myosin |
| 亚基 | Interacts with PLEKHB1 (via PH domain). Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. Binds MYRIP and WHRN. |
| 亚细胞定位 | Cytoplasm (Probable). Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. |
| 组织特异性 | Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain. |
| 相似性 | Contains 2 FERM domains. Contains 5 IQ domains. Contains 1 myosin head-like domain. Contains 2 MyTH4 domains. Contains 1 SH3 domain. |
| 功能 | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, myosin VIIa might play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, myosin VIIa may play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it may maintain the rigidity of stereocilia during the dynamic movements of the bundle. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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Myosin VIIa Rabbit pAb, HRP conjugated(bs-25756R-HRP)-100ul
￥2980
