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- bs-11548R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-11548R-Bio |
| 英文名称 | phospho-Dab1 (Tyr198) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化磷脂蛋白受体Dab1抗体 |
| 英文别名 | Dab1(phospho Y198); Dab1(phospho-Tyr198); Dab 1; Dab1; Dab-1; DAB1_HUMAN; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr198 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Signal Transduction > Protein Trafficking > Vesicle Transport > Adapters |
| 亚基 | Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1. |
| 翻译后修饰 | Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling. |
| 相似性 | Contains 1 PID domain. |
| 功能 | Adapter molecule functioning in neural development. May regulate SIAH1 activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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phospho-Dab1 (Tyr198) Rabbit pAb, Biotin conjugated(bs-11548R-Bio)-100ul
￥2980
