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- bs-0821R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-0821R-Bio |
| 英文名称 | Laminin subunit beta-1 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的层粘连蛋白β1抗体 |
| 英文别名 | LAMB1; Laminin B1 chain; Laminin subunit beta 1; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; LAMB1_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ELISA=1:5000-10000, WB=1000-10000, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Laminin subunit beta-1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Signal Transduction > Cytoskeleton / ECM > Basal Lamina |
| 亚基 | Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). |
| 亚细胞定位 | Secreted > extracellular space > extracellular matrix > basement membrane. |
| 组织特异性 | Broadly expressed in: skin, heart, lung, and the reproductive tracts. |
| 相似性 | Contains 17 laminin EGF-like domains. _x000D_ Contains 5 laminin G-like domains. _x000D_ Contains 2 laminin IV type A domains. _x000D_ Contains 1 laminin N-terminal domain. |
| 功能 | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
| {WB} | {1000-10000} |
| {IF} | {1:100-500} |
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Laminin subunit beta-1 Rabbit pAb, Biotin conjugated(bs-0821R-Bio)-100ul
￥2980
