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- bsm-2000M-Bio
- 2025年09月30日
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100ul
| 产品编号 | bsm-2000M-Bio |
| 英文名称 | HBcAg Mouse mAb, Biotin conjugated |
| 中文名称 | Biotin标记的人乙型肝炎核心抗原单克隆抗体 |
| 英文别名 | C; core; E; PC; pre-C; pre-C/C; PreC; PreC/C; precore-core; Capsid protein; Core and e antigen; Core antigen; Core protein; HBc; HBVgp4; Hepatitis B Virus core antigen; p21.5; precore/core protein; Q89714_HBV. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinded human hepatitis B core antigen protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Viral proteins > Hepatitis B Microbiology > Organism > Virus > DNA Virus > double stranded DNA Virus > Hepatitis B |
| 亚基 | Homodimerizes, then multimerizes. Interacts with cytosolexposed regions of viral L glycoprotein present in thereticulum-to-Golgi compartment. Interacts with human FLNB. |
| 亚细胞定位 | Capsid protein: Virion. Host cytoplasm. |
| 翻译后修饰 | Phosphorylated by host SRPK1, SRPK2, and maybe protein kinaseC or GAPDH. Phosphorylation is critical for pregenomic RNApackaging. Protein kinase C phosphorylation is stimulated by HBxprotein and may play a role in transport of the viral genome to thenucleus at the late step during viral replication cycle. |
| 相似性 | Belongs to the orthohepadnavirus core antigen family. |
| 功能 | Self assembles to form an icosahedral capsid. Mostcapsid appear to be large particles with a icosahedral symmetry ofT=4 and consist of 240 copies of capsid protein, though a fractionforms smaller T=3 particles consisting of 180 capsid proteins.Entering capsid are transported along microtubules to the nucleus.Phosphorylation of the capsid is thought to induce exposure ofnuclear localization signal in the C-terminal portion of the capsidprotein that allows binding to the nuclear pore complex via theimportin (karyopherin-) alpha and beta. Capsids are imported inintact form through the nuclear pore into the nuclear basket, whereit probably binds NUP153. Only capsids that contain the matureviral genome can release the viral DNA and capsid protein into thenucleoplasm. Immature capsids get stucked in the basket. Capsidsencapsulate the pre-genomic RNA and the P protein. Pre-genomic RNAis reverse transcribed into DNA while the capsid is still in thecytoplasm. The capsid can then either be directed to the nucleus,providing more genome for transcription, or bud through theendoplasmic reticulum to provide new virions (By similarity). Encapsidates hepatitis delta genome. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验【翻译】Development trends for monoclonal antibody cancer therapeutics
7 and patients frequently developed antibodies to the mouse-derived proteins, which limited their utility8, 9. In addition, only certain murine mAb isotypes have been shown to effectively bind to and activate elements of the human immune
The Use of Quantum Dots for Immunochemistry Applications
the anti-mouse IgG antibody directly conjugated to QD655 quantum dots or anti-mouse IgG conjugated to biotin for tertiary detection with streptavidin-conjugated QD655.
- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
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