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- Bioss
- bs-4276R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-4276R-Bio |
| 英文名称 | ELAC2/HPC2 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的遗传性前列腺癌蛋白2抗体 |
| 英文别名 | elaC homolog 2; ElaC homolog protein 2; ELC2; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z2; RNase Z2; tRNA 3 endonuclease 2; tRNase Z(long form); tRNase Z2; Zinc phosphodiesterase ELAC protein 2; RNZ2_HUMAN; Ribonuclease Z 2; RNase Z 2. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ELAC2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing |
| 亚基 | Homodimer. Interacts with PTCD1. |
| 亚细胞定位 | Mitochondrion. Nucleus. Note=Mainly mitochondrial. |
| 组织特异性 | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. |
| 相似性 | Belongs to the RNase Z family. |
| 功能 | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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ELAC2/HPC2 Rabbit pAb, Biotin conjugated(bs-4276R-Bio)-100ul
￥2980
