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- Bioss
- bs-2013R-APC
- 2025年10月15日
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| 产品编号 | bs-2013R-APC |
| 英文名称 | phospho-Nrf2 (Ser40) Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的磷酸化核因子2相关因子2(Ser40)抗体 |
| 英文别名 | Nrf2(phospho S40); p-Nrf2(phospho S40); Nuclear factor-E2 related factor2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN. |
| 产品应用 | ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Cell Biology > Other Antibodies > Oxidative Stress Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies Epigenetics and Nuclear Signaling > Transcription > Other factors Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Molecular processes > Mitochondrial transcription Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial Biogenesis Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress |
| 亚基 | Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. |
| 亚细胞定位 | Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. |
| 组织特异性 | Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. |
| 翻译后修饰 | Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. |
| 相似性 | Belongs to the bZIP family. CNC subfamily. Contains 1 bZIP domain. |
| 功能 | Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptionfactor which regulates the expression of many detoxification andantioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar (CNC-bZIP) subfamily of basic /leucine zipper (bZIP) transcription factors. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
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文献和实验Generation of Dendritic Cells from Lymphoid Precursors
Dendritic cells (DC) are “professional” antigen presenting cells (APC) that are pivotal for the initiation of T-cell-dependent immune responses (1 ). DC are widely distributed cells in the body, but are scarce and thus difficult to purify
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