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产品信息以Bioss网站为准
- 规格:
100ul
| 产品编号 | bs-17696R-Bio |
| 英文名称 | phospho-MNK1 (Thr250) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化MAP激酶相互作用丝氨酸/苏氨酸激酶1抗体 |
| 英文别名 | MNK1(phospho T250); p-MNK1(phospho T250); MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal integrating kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal integrating kinase 1; MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1; MKNK1; MKNK1_HUMAN; MNK 1; Mnk1. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human MNK1 around the phosphorylation site of Thr250 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Cytoplasm and Cytoplasm. Nucleus. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. |
| 相似性 | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. _x000D_ Contains 1 protein kinase domain. |
| 功能 | May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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phospho-MNK1 (Thr250) Rabbit pAb, Biotin conjugated(bs-17696R-Bio)-100ul
¥2980






