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- Bioss
- bs-20838R-Bio
- 2025年10月15日
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100ul
| 产品编号 | bs-20838R-Bio |
| 英文名称 | LY6E Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的T淋巴细胞激活蛋白6E抗体 |
| 英文别名 | Ly-6E; LY6E_HUMAN; LY6E_MOUSE; Lymphocyte antigen 6E; Retinoic acid-induced gene E protein; RIG-E; RIGE; SCA2; TSA1; 9804; SCA-2; Stem cell antigen 2; Thymic shared antigen 1; TSA-1 . |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse LY6E |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 组织特异性 | Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes. |
| 相似性 | Contains 1 UPAR/Ly6 domain. |
| 功能 | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
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