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- Bioss
- bs-1847R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-1847R-Bio |
| 英文名称 | MAP1A Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的微管相关蛋白1A抗体 |
| 英文别名 | MAP 1A; MAP-1A; MTAP1A; MAP 1L; MAP1L; MAP1A heavy chain; Map1a; MAP1A_HUMAN; Microtubule associated protein 1 like; Microtubule Associated Protein 1A; Microtubule-associated protein 1A; MTAP1A; Proliferation related protein p80; Proliferation-related protein p80; AI853608; Map1a; moth1; Mtap-1; Mtap1. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MAP1A heavy chain |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Autophagy > APG gene products Cancer > Cell Death > Autophagy > Autophagosome Cancer > Cell Death > Autophagy > Signal Transduction Cancer > Signal transduction Cancer > Signal transduction > Autophagy Cardiovascular > Heart > Autophagy > APG gene products Cardiovascular > Heart > Autophagy > Autophagosome Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > Autophagosome Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > MT Associated Proteins > MAP |
| 亚基 | 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. |
| 组织特异性 | Most abundant in placenta, lung and ovary. |
| 翻译后修饰 | Phosphorylated by CSNK1D._x000D_
LC2 is generated from MAP1A by proteolytic processing. |
| 相似性 | Belongs to the MAP1 LC3 family. |
| 功能 | Probably involved in formation of autophagosomal vacuoles (autophagosomes). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. There are three isoforms of human LC3 (named MAP1LC3A, MAP1LC3B, and MAP1LC3C), which exhibit different tissue distributions. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {1ug/test} |
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