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- Bioss
- bs-16682R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-16682R-Bio |
| 英文名称 | phospho-GRK2 (Ser670) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化G蛋白偶合受体激酶2抗体 |
| 英文别名 | GRK2(phospho S670); p-GRK2(phospho S670); G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; beta adrenergic receptor kinase 1; beta ARK 1; beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN. |
| 产品应用 | ELISA=1:5000-10000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser670 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Adrenergic Receptors Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1. |
| 组织特异性 | Expressed in peripheral blood leukocytes. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. _x000D_ Contains 1 AGC-kinase C-terminal domain. _x000D_ Contains 1 PH domain. _x000D_ Contains 1 protein kinase domain. _x000D_ Contains 1 RGS domain. |
| 功能 | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:5000-10000} |
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phospho-GRK2 (Ser670) Rabbit pAb, Biotin conjugated(bs-16682R-Bio)-100ul
￥2980
