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- Bioss
- bs-16798R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-16798R-BF350 |
| 英文名称 | KMT5A Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的组蛋白H4 K20甲基转移酶抗体 |
| 英文别名 | KMT5A_HUMAN; N-lysine methyltransferase KMT5A; H4-K20-HMTase KMT5A; AltName: Full=Histone-lysine N-methyltransferase KMT5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; PR/SET domain-containing protein 07; PR-Set7; PR/SET07; SET domain-containing protein 8. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human KMT5A |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Nucleus. Chromosome. Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. |
| 相似性 | Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. _x000D_ Contains 1 SET domain. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
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KMT5A Rabbit pAb, BF350 conjugated(bs-16798R-BF350)-100ul
￥2980
