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USP3 Rabbit pAb, AP conjugated

(bs-4806R-AP)-100ul
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  • ￥2980
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  • bs-4806R-AP
  • 2025年09月30日
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-4806R-AP
    英文名称USP3 Rabbit pAb, AP conjugated
    中文名称AP标记的去泛素化酶3抗体
    英文别名Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human USP3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Deubiquitination

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Ubiquitylation

    Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > Deubiquitination

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism

    Metabolism > Types of disease > Cancer

    Signal Transduction > Metabolism > Amino Acids

    亚基Interacts (via UBP-type domain) with H2A; the interaction is less efficient than with monoubiquitinated H2A.
    亚细胞定位Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
    组织特异性Expressed in all tissues examined, with strongest expression in pancreas.
    相似性Belongs to the peptidase C19 family. USP3 subfamily.
    Contains 1 UBP-type zinc finger.
    功能Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP3 (ubiquitin specific peptidase 3), also known as UBP or SIH003, is a 520 amino acid protein that contains one UBP-type zinc finger and belongs to the peptidase C19 family. Expressed ubiquitously with highest levels present in pancreas, USP3 catalyzes the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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    图标文献和实验
    相关实验

    • Western 杂交

      SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts.    ・        

    • Developing Genetically Engineered Mouse Models to Study Tumor Suppression

      Literature Cited    Armstrong, J.F., Kaufman, M.H., Harrison, D.J., and Clarke, A.R. 1995. High‐frequency developmental abnormalities in p53‐deficient mice. Curr

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