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- bs-2132R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-2132R-HRP |
| 英文名称 | Angiotensin II type 1A receptor Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的血管紧张素Ⅱ1A型受体抗体 |
| 英文别名 | AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Cellular metabolic process Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Blood > Blood Pressure regulation Metabolism > Types of disease > Cancer |
| 亚基 | Interacts with MAS1 (Probable). Interacts with ARRB1. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Liver, lung, adrenal and adrenocortical adenomas. |
| 翻译后修饰 | C-terminal Ser or Thr residues may be phosphorylated. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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文献和实验Peptide-Conjugated Quantum Dots: Imaging the Angiotensin Type 1 Receptor in Living Cells
. These conjugates have been used to image angiotensin I-expressing Chinese hamster ovary (CHO) cells in vitro. When CHO cells were incubated with Ang II before incubating with Ang II-conjugated quantum dots, we were able to block the binding of the dots. The Ang II
Characterization of Angiotensin II Receptors
. Hypertension 25:924‐927. Feral, C., Benhaim, A., and Leymarie, P. 1996. Angiotensin II receptor type I on granulosa and thecal cells of rabbit preovulatory follicles. Biochim
Radioligand Binding Assays: Application of [125I]Angiotensin II Receptor Binding
target in patients with high blood pressure. Strategies to lower high blood pressure (hypertension) include the use of drugs that compete for AngII at the angiotensin II Type 1 receptors (ATR) using ATR antagonists (e.g., irbesartan, valsartan
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