Caspase-12 Rabbit pAb, HRP conjugated(bs-1105R-HRP)-100ul

Caspase-12 Rabbit pAb, HRP con

jugated(bs-1105R-HRP)-100ul
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  • ￥2980
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  • bs-1105R-HRP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-1105R-HRP
    英文名称Caspase-12 Rabbit pAb, HRP conjugated
    中文名称HRP标记的半胱胺酸蛋白酶蛋白-12抗体
    英文别名UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12(gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from the middle of human Caspase-12
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Apoptosis Markers > Caspases

    Cancer > Cell Death > Apoptosis > Metabolism

    Cancer > Invasion/microenvironment > Apoptosis > Caspases

    Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Proteases

    组织特异性Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
    相似性Belongs to the peptidase C14A family.
    Contains 1 CARD domain.
    功能Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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