Vitamin D Receptor Rabbit pAb, Cy7 conjugated(bs-2987R-Cy7)-100ul

Vitamin D Receptor Rabbit pAb,

Cy7 conjugated(bs-2987R-Cy7)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-2987R-Cy7
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bs-2987R-Cy7
    英文名称Vitamin D Receptor Rabbit pAb, Cy7 conjugated
    中文名称Cy7标记的维生素D3受体抗体
    英文别名Vitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 1 antibody 1, 25-@dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; Vitamin D(1, 25-dihydroxyvitamin D3) receptor; Vitamin D hormone receptor; Vitamin D receptor; Vitamin D3 receptor,
    产品应用IF=1:100-500, ICC/IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Vitamin D Receptor
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors

    Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Vitamin D Receptor

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger

    Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Vitamin D Receptor

    亚基Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.
    亚细胞定位Nucleus.
    相似性Belongs to the nuclear hormone receptor family. NR1 subfamily._x000D_
    Contains 1 nuclear receptor DNA-binding domain.
    功能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone ensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

     

    应用推荐稀释比例
    {IF}{1:100-500}
    {ICC/IF}{1:100-500}

     

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