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- Bioss
- bs-1201R-APC-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-1201R-APC-Cy7 |
| 英文名称 | PAX8 Rabbit pAb, APC-Cy7 conjugated |
| 中文名称 | APC-Cy7标记的配对盒基因8抗体 |
| 英文别名 | Paired Box Gene 8; paired box homeotic gene 8; Paired box protein Pax 8; Paired Domain Gene 8; PAX 8; PAX-8; PAX8_HUMAN. |
| 产品应用 | Flow-Cyt=1μg/Test, ICC/IF=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PAX8 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > PAX Neuroscience > Sensory System > Auditory system |
| 亚基 | Interacts with WWTR1. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in the excretory system, thyroid gland and Wilms tumors. |
| 翻译后修饰 | S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. |
| 相似性 | Contains 1 paired domain. |
| 功能 | Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
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PAX8 Rabbit pAb, APC-Cy7 conjugated(bs-1201R-APC-Cy7)-100ul
￥2980
