Estrogen receptor beta Rabbit pAb, BF405 conjugated(bs-0116R-BF405)-100ul

Estrogen receptor beta Rabbit

pAb, BF405 conjugated(bs-0116R-BF405)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-0116R-BF405
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-0116R-BF405
    英文名称Estrogen receptor beta Rabbit pAb, BF405 conjugated
    中文名称BF405标记的雌激素受体β 抗体
    英文别名Estrogen receptor-beta; Estrogen receptor beta; ER BETA; ER-BETA; ER-beta; Erb; ESR 2; ESR 2; ESR B; ESR-B; ESR BETA; ESR-BETA; ESR2; ESR2; ESR2_HUMAN; ESRB; ESTRB; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor 2(ER beta); Estrogen Receptor 2; Estrogen Receptor-2; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2.
    产品应用IF=1:100-500, ICC/IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ER-beta
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Estrogen

    Cancer > Tumor biomarkers > Receptors

    Epigenetics and Nuclear Signaling > ChIP assays > ChIP kits

    Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Estrogen

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger

    Neuroscience > Endocrine system > Gonadotrophic axis

    Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Estrogen

    亚基 Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.
    亚细胞定位Nucleus.
    组织特异性Tissue specificityIsoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
    翻译后修饰Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity._x000D_
    Glycosylated; contains N-acetylglucosamine, probably O-linked._x000D_
    相似性Belongs to the nuclear hormone receptor family. NR3 subfamily._x000D_
    Contains 1 nuclear receptor DNA-binding domain._x000D_
    功能 Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a member of the family of estrogenreceptors and superfamily of nuclear receptor transcriptionfactors. The gene product contains an N-terminal DNA binding domainand C-terminal ligand binding domain and is localized to thenucleus, cytoplasm, and mitochondria. Upon binding to17beta-estradiol or related ligands, the encoded protein formshomo- or hetero-dimers that interact with specific DNA sequences toactivate transcription. Some isoforms dominantly inhibit theactivity of other estrogen receptor family members. Severalalternatively spliced transcript variants of this gene have beendescribed, but the full-length nature of some of these variants hasnot been fully characterized. [provided by RefSeq, Jul 2008].

     

    应用推荐稀释比例
    {IF}{1:100-500}
    {ICC/IF}{1:50-200}

     

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