PDCD1LG2 | CD273/B7-DC/PD-L2 Rabbit pAb, APC-Cy7 conj.(bs-1868R-APC-Cy7)-100ul产品图

PDCD1LG2 | CD273/B7-DC/PD-L2 R

abbit pAb, APC-Cy7 conj.(bs-1868R-APC-Cy7)-100ul
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  • bs-1868R-APC-Cy7
  • 2026年10月17日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-1868R-APC-Cy7
    英文名称PDCD1LG2 Rabbit pAb, APC-Cy7 conjugated
    中文名称APC-Cy7标记的程序性死亡配体2（CD273）抗体
    英文别名PD L2; PD-L2; PD1L2_HUMAN; B7 dendritic cell molecule; B7-DC; B7DC; bA574F11.2; Btdc; Butyrophilin B7 DC; Butyrophilin B7-DC; Butyrophilin B7DC; CD 273; CD273; CD273 antigen; MGC142238; MGC142240; PD 1 ligand 2; PD-1 ligand 2; PD1 ligand 2; PDCD 1 ligand 2; PDCD1 ligand 2; PDCD1L2; PDL 2; PDL2; Programmed cell death 1 ligand 2; Programmed death ligand 2.
    产品应用Flow-Cyt=1ug/Test, ICC/IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PDCD1LG2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Immunology > Immunoglobulins > Receptors

    亚基Interacts with PDCD1.
    亚细胞定位Isoform 3: Secreted (Probable)._x000D_
    Isoform 2: Endomembrane system; Single-pass type I membrane protein._x000D_
    Isoform 1: Cell membrane; Single-pass type I membrane protein.
    组织特异性Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
    翻译后修饰Phosphorylated by AKT1. Phosphorylation relieves inhibitory function on mTORC1.
    相似性Belongs to the immunoglobulin superfamily. BTN/MOG family._x000D_
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain._x000D_
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    功能Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料B7DC is a 33kDa member of the immunoglobulin receptor superfamily expressed on DC, liver and a small subset of macrophages as well as a few transformed cell lines. B7DC has been reported to be stimulatory on dendritic cells when cross linked and to inhibit T cell activation upon engaging the PD1 receptor. B7DC has also been reported to bind to an alternative receptor and to mediate T cell activation through non PD1 mediated interactions.

     

    应用推荐稀释比例
    {Flow-Cyt}{1ug/Test}
    {ICC/IF}{1:100-500}

     

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