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- bs-5039R-FITC
- 2025年09月30日
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100ul
| 产品编号 | bs-5039R-FITC |
| 英文名称 | Apolipoprotein E3 Rabbit pAb, FITC conjugated |
| 中文名称 | FITC标记的载脂蛋白E3抗体 |
| 英文别名 | AD2; APOE3; ApoEb; Apolipoprotein EIII; Apolipoprotein E; APOE_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human APOE3 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins Cardiovascular > Atherosclerosis > Lipid transport Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins Developmental Biology > Lineage specification > Endoderm Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Metabolism > Types of disease > Heart disease Metabolism > Types of disease > Neurodegenerative disease Neuroscience > Neurology process > Neurodegenerative disease Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Metabolism > Lipid metabolism Stem Cells > Lineage Markers > Endoderm |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle. |
| 翻译后修饰 | Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 is a minor glycosylation site compared to Ser-308._x000D_
Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold)._x000D_ Phosphorylation sites are present in the extracellular medium. |
| 相似性 | Belongs to the apolipoprotein A1/A4/E family. |
| 功能 | Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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