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- bs-0522R-Cy5
- 2025年09月30日
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100ul
| 产品编号 | bs-0522R-Cy5 |
| 英文名称 | CD45 Rabbit pAb, Cy5 conjugated |
| 中文名称 | Cy5标记的白细胞共同抗原CD45抗体 |
| 英文别名 | B220; CD 45; CD-45; cd45 antigen; ec3.1.3.48; CD45R; GP180; GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase, receptor type, C; Receptor-type tyrosine-protein phosphatase C; PTPRC; PTPRC_HUMAN; SCID due to PTPRC deficiency; T200; T200 glycoprotein; T200 leukocyte common antigen; Human homolog of severe combined immunodeficiency due to PTPRC deficiency. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD45 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Immunology > Adaptive Immunity > B Cells > CD Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Adaptive Immunity > T Cells > CD Immunology > Cell Type Markers > CD > Non-lineage Neuroscience > Cell Type Marker > Glia marker > Microglia marker Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Dendritic Cell Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Mast Cell Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage Stem Cells > Hematopoietic Progenitors > Surface Molecules |
| 亚基 | Binds GANAB and PRKCSH. Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes._x000D_ Contains 2 tyrosine-protein phosphatase domains. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. |
| 翻译后修饰 | Heavily N- and O-glycosylated. |
| 相似性 | Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. |
| 功能 | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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文献和实验CXCR5和Ly108（SLAMF6），部分还高表达CD62L；过渡性耗竭T细胞（TEX-Trans）为CD101−TIM3+；终末耗竭T细胞（TEX-Term）则表现为CD101+TIM3+CD69+；而效应样耗竭T细胞（eff-like TEX）高表达KLRG1和CX3CR1。相比之下，在急性感染中，效应T细胞（TEFF）为KLRG1hiCD127lo，记忆前体细胞（TMP）为KLRG1loCD127hi。记忆T细胞进一步分为：干细胞样记忆（TSCM，CD62L+CD45RA+CCR7+IL-7R
标记CD34抗体，PE-CY5标记CD45抗体。流式细胞仪要求：488nm光源，525nm、575nm、675nm滤光片，液量绝对计数系统。⑸、交叉淋巴细胞、粒细胞毒实验检测识别供体血清中免疫球蛋白与受体粒细胞之间是否存在反应有着重要临床意义，因为这种反应会导致移植后发热、移植后肺损伤及免疫性粒细胞缺乏症。流式细胞仪可检测全血样本与血清孵育后粒细胞上结合的人免疫球蛋白。FITC标记人免疫球蛋白抗体、PE标记粒细胞表面标志物、PE-CY5标记HLA抗体。流式细胞仪要求：488nm光源，525nm、575
Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
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