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- Bioss
- bs-8551R-Cy3
- 2025年10月15日
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100ul
| 产品编号 | bs-8551R-Cy3 |
| 英文名称 | 3-Nitrotyrosine Rabbit pAb, Cy3 conjugated |
| 中文名称 | Cy3标记的硝基酪氨酸/硝基化酪氨酸抗体 |
| 英文别名 | NO tyrosine; nTyr; Nitrotyrosine; nitro-Tyrosine; nitro Tyrosine. |
| 中文别名 | 酪氨酸硝基化； |
| 产品应用 | Flow-Cyt=1μg/Test, IF=1:50-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Nitrotyrosine |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Signal transduction proteins ELISA kits Signal Transduction > Metabolism > Amino Acids |
| 亚细胞定位 | Cytoplasm. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nitrotyrosine is a marker for inflammation and nitric oxide (NO) production and is formed in the presence of the active metabolite NO. Because nitrotyrosine is a stable product of multiple pathways, such as the formation of peroxynitrite, its plasma concentration may be a useful determinant of NO-dependent damage in vivo. Nitrotyrosine has been detected in inflammatory processes such as septic shock, rheumatoid arthritis, celiac disease, atherosclerotic plaques and chronic renal failure.Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A, SP-A, to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {IF} | {1:50-200} |
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文献和实验[IF={{ 7.67 }}] {Vendrov, Aleksandr, et al. "NOX4 NADPH Oxidase-dependent Mitochondrial Oxidative Stress in Aging-associated Cardiovascular Disease." Antioxidants and Redox Signaling ja (2015).} {IHC} {="Mouse"}
Construction and Use of Glycan Microarrays
) Printing buffer (see recipe ) Controls: unmodified BSA and HSA (negative controls) and BSA conjugated with Cy3 or Alexa Fluor 647
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