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- bs-1281R-PerCP
- 2025年09月30日
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100ul
| 产品编号 | bs-1281R-PerCP |
| 英文名称 | XIAP/BIRC4 Rabbit pAb, PerCP conjugated |
| 中文名称 | PerCP标记的X-连锁凋亡蛋白/性连锁凋亡抑制蛋白抗体 |
| 英文别名 | X-linked Inhibitor of Apoptosis Protein; RIAP-3; Baculoviral IAP repeat-containing protein 4; E3 ubiquitin-protein ligase XIAP; Inhibitor of apoptosis protein 3; X-linked IAP; IAP-like protein; HILP; BIRC4; HILP; XLP2; ILP1; Xiap; MIHA; hILP; IAP3; API3; XIAP; XIAP_HUMAN; ILP; hILP; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein. |
| 产品应用 | Flow-Cyt=3ug/Test, ICC/IF=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human XIAP |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Apoptosis Markers > Caspases Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > IAPs Cancer > Invasion/microenvironment > Apoptosis > Caspases Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > IAPs Cell Biology > Apoptosis > Intracellular > Caspases etc > Inhibitors Cell Biology > Apoptosis > Intracellular > Survivin / IAPs Metabolism > Pathways and Processes > Metabolism processes > Apoptosis |
| 亚基 | Monomer, and homodimer. Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of MAP3K7IP1 and AIFM1. Interacts with TCF25. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Ubiquitous, except peripheral blood leukocytes. |
| 翻译后修饰 | Ubiquitinated and degraded by the proteasome in apoptotic cells._x000D_ Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation. |
| 相似性 | Belongs to the IAP family._x000D_
Contains 3 BIR repeats._x000D_ Contains 1 RING-type zinc finger. |
| 功能 | Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3ug/Test} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
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XIAP/BIRC4 Rabbit pAb, PerCP conjugated(bs-1281R-PerCP)-100ul
￥2980
