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- bs-2459R-AP
- 2025年09月30日
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| 产品编号 | bs-2459R-AP |
| 英文名称 | IL-10RA Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的白细胞介素-10受体a抗体 |
| 英文别名 | Interleukin-10 Receptor; CD210; CDW210A; CDw210a; CDw210a antigen; HIL 10R; HIL10R; IL 10R 1; IL 10R A; IL 10R; IL10RA; IL 10R1; IL10R; IL10R1; Interleukin 10 receptor alpha; Interleukin 10 receptor alpha chain; I10R1_HUMAN; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; Interleukin-10 receptor bunit 1; IL-10R subunit 1; IL-10R1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IL-10RA |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels. |
| 相似性 | Belongs to the type II cytokine receptor family. |
| 功能 | Receptor for IL10; binds IL10 with a high affinity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验of miR-155 in this response are IL-10 and the transcription factor c-Maf. Precise roles for miR-155 in supporting or terminating the development of an innate immune response in macrophages have yet to be demonstrated (24). miR-155 may act
信号；⑤进一步活化的T细胞更多表达CD401。和分泌细胞因子，其中较重要的如IL-4。与B细胞表面的IL-4R结合．促使B细胞进一步活化并开始增殖分化。参与B激活的其他分子还包括CD30与CD30L(CDl53)、41BB与41BBL、B7-RP与ICOS等，细胞因子IL-5和II．-6则在B细胞激活的后期发挥作用。 图10-7 T细胞与B细胞之间的相互作用图中圆圈内由文字代表第二信号；注意最终生成的抗体是针对抗原B表位(绿色)而非T表位(红色)。2.T、B细胞相互作用的特异性 需要指出
的GR可结合于AP-1从而抑制胶原酶的合成。AP-1还参与T细胞的活化，促进IL-2及IL-2R基因的表达等，GC则通过GR的活化而AP-1的活性以对抗细胞因子的作用。其它转录因子如NF-κB及NF-AT等也受GC的负性调控。此领域的研究将对合理的药物设计及相关的临床实践具有指导意义。 2.龙激素 一般而言，睾酮等雄激不经对免疫功能有抑制性作用。睾酮可减少人泪腺中IgA的产生，这一作用为雄激素所独有。在睾酮的作用下，胸腺的重量和体积均减少。小鼠迟发型皮肤超敏反应及抗体的生成亦受睾酮的抑制
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