ACTR3 | ARP3 Rabbit pAb, BF405 conj.(bs-7119R-BF405)-100ul产品图

ACTR3 | ARP3 Rabbit pAb, BF405

conj.(bs-7119R-BF405)-100ul
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  • ¥2980
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  • bs-7119R-BF405
  • 2026年10月17日
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    • 技术资料
    • 规格:

      100ul

    产品编号bs-7119R-BF405
    英文名称ARP3 Rabbit pAb, BF405 conjugated
    中文名称BF405标记的细胞骨架肌动蛋白样蛋白3抗体
    英文别名Actin-like protein 3; Actin-related protein 3; ACTR3; ARP3 actin-related protein 3 homolog; ARP3_HUMAN.
    产品应用ICC/IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ARP3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Immunology > Innate Immunity > Macrophage / Inflamm.

    Tags & Cell Markers > Subcellular Markers > Organelles > Golgi

    亚基Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1.
    亚细胞定位Cytoplasm, cytoskeleton. Cell projection.
    相似性Belongs to the actin family. ARP3 subfamily.
    功能The Arp2/3 complex involved in Golgi polerization in NIH3T3 cells. In a different model it has been shown that the Arp2/3 complex is necessary for neutrophil chemotaxis and phagocytosis.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Actin polymerization is required for a variety of cell functions, including chemotaxis, cell migration, cell adhesion, and platelet activation. Cells trigger actin polymerization through either the de novo nucleation of filaments from monomeric actin, the severing of existing filaments to create uncapped barbed ends, or the uncapping existing barbed ends. The nucleation of actin is a rate-limiting and unfavorable reaction in actin polymerization and therefore requires the involvement of the Arp2/3 complex, which helps create new filaments and promotes the end-to-side cross-linking of actin filaments into the branching meshwork. The Arp2/3 complex consists of the actin-related proteins Arp2 and Arp3, and various other accessory proteins. The Arp2/3 complex promotes actin nucleation by binding the pointed end of actin filaments, or by associating with the side of an existing filament, and nucleates growth in the barbed direction. In addition, the Arp2/3 complex also mediates actin cytoskeletal outgrowths that are regulated by the Rho family of small GTPases. In response to GTP-binding Cdc42, the Arp2/3 complex binds the Cdc42 substrates, namely the WASP proteins, and initiates the formation of lamellipodia and filopodia.

     

    应用推荐稀释比例
    {ICC/IF}{1:100-500}

     

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