SCARB1/Scavenger Receptor BI Rabbit pAb, AP conjugated(bs-23976R-AP)-100ul产品图

SCARB1/Scavenger Receptor BI R

abbit pAb, AP conjugated(bs-23976R-AP)-100ul
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  • bs-23976R-AP
  • 2025年09月30日
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    • 规格：

      100ul

    产品编号bs-23976R-AP
    英文名称SCARB1/Scavenger Receptor BI Rabbit pAb, AP conjugated
    中文名称AP标记的高密度脂蛋白受体/清道夫受体抗体
    英文别名HDL-R; High Density Lipoprotein Receptor; CD36 Antigen like 1; CD36L1; CLA 1; CLA1; SR BI; SRB1; SRBI; Scavenger Receptor BI; CD36 AND LIMPII ANALOGOUS 1; CD36 Antigen like 1; CD36L1; CLA 1; CLA1; Collagen type I receptor; MGC138242; SCARB1; Scavebger Receptor Class B Member 1; Scavenger Receptor Class B Type 1; SR BI; SRB1; SRBI; Thrombospondin receptor like 1; High density lipoprotein receptor SR-BI.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SCARB1/Scavenger Receptor BI
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins

    Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

    Microbiology > Interspecies Interaction > Host Virus Interaction

    Signal Transduction > Metabolism > Lipid metabolism

    亚基Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1.
    亚细胞定位Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
    组织特异性Widely expressed.
    _x000D_ The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
    翻译后修饰N-glycosylated.
    相似性Belongs to the CD36 family.
    功能Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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