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- bs-1919R-PE-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-1919R-PE-Cy5.5 |
| 英文名称 | TLR1 Rabbit pAb, PE-Cy5.5 conjugated |
| 中文名称 | PE-Cy5.5标记的Toll样受体1抗体 |
| 英文别名 | Toll-like receptor 1; GD2:CD281; CD281 antigen; rsc786; Similar to Drosophila Toll protein; TIL; Toll(Drosophila) homolog; Toll like receptor 1 Precursor; Toll/Interleukin 1 receptor like; TLR1_HUMAN. |
| 产品应用 | Flow-Cyt=1μg /test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TLR1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling Signal Transduction > Adapters > Transmembrane Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway |
| 亚基 | Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). |
| 组织特异性 | Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. |
| 相似性 | Belongs to the Toll-like receptor family._x000D_
Contains 19 LRR (leucine-rich) repeats._x000D_ Contains 1 LRRCT domain._x000D_ Contains 1 TIR domain. |
| 功能 | Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TLR1 is a member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The gene encoding TLR1 is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /test} |
| {IF} | {1:100-500} |
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文献和实验Fluorochrome Absorption and Emission Spectra
conjugates to monoclonal antibodies and other proteins. Four of these fluorochromes, fluorescein isothiocyanate (FITC), R-phycoerythrin (R-PE), BD Cy-Chrome™, and PerCP, can be used with single-laser flow cytometers equipped with an argon-ion laser emitting
Fluorochrome Absorption and Emission
to monoclonal antibodies and other proteins. Four of these fluorochromes, fluorescein isothiocyanate (FITC), R-phycoerythrin (R-PE), BD Cy-Chrome™, and PerCP, can be used with single-laser flow cytometers equipped with an argon-ion laser emitting light at 488 nm
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