- ￥2980
- Bioss
- bs-2680R-APC-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-2680R-APC-Cy5.5 |
| 英文名称 | NFAM1 Rabbit pAb, APC-Cy5.5 conjugated |
| 中文名称 | APC-Cy5.5标记的NFAM1抗体 |
| 英文别名 | NFAT activation molecule 1 precursor; NFAT activation molecule 1 precursor; Calcinerin/NFAT activating ITAM containing protein; CNAIP; NFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1; NFAM1_HUMAN. |
| 产品应用 | Flow-Cyt=1μg /test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NFAM1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFATs Immunology > Innate Immunity > Cytokines > Interleukins Immunology > Innate Immunity > Cytokines > TNF Superfamily Signal Transduction > Signaling Pathway > Nuclear Signaling > NFATS |
| 亚基 | Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR). |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation. |
| 组织特异性 | Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 1 ITAM domain. |
| 功能 | May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NFAM1 activates cytokine gene promoters such as the IL13 and TNF-alpha promoters. It contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /test} |
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文献和实验Fluorochrome Absorption and Emission Spectra
light at 488 nm for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes
Fluorochrome Absorption and Emission
for three-color flow cytometric analysis (Fig. 1). BD Biosciences Pharmingen also offers monoclonal antibodies and proteins conjugated to allophycocyanin (APC) and avidin conjugated to Texas Red™. Both of these dyes are useful in experiments
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