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- bs-7118R-PerCP-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-7118R-PerCP-Cy7 |
| 英文名称 | TRIP4 Rabbit pAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的甲状腺激素受体相互作用蛋白4抗体 |
| 英文别名 | Activating signal cointegrator 1; ASC1; ASC 1; ASC-1; HsT17391; Thyroid hormone receptor interactor 4; Thyroid receptor interacting protein 4; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP 4; TRIP-4; TRIP4; TRIP4_HUMAN. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TRIP4/ASC |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription |
| 亚基 | Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and HELIC1. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and dihydrotestosterone-dependent manner (By similarity). Interacts with NEK6. |
| 亚细胞定位 | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic under conditions of serum deprivation. Co-localizes with NEK6 in the centrosome. |
| 翻译后修饰 | Phosphorylated by NEK6. |
| 功能 | Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm. However, when serum starved in the presence of ligand of coexpressed CBP or SRC-1, ASC-1 remains in the nucleus. This behavior of ASC-1 suggests that it may play an important role in establishing distinct co-activator complexes under different cellular conditions. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
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文献和实验Fluorochrome Absorption and Emission Spectra
. Using a 650 nm longpass filter will give optimum detection for this fluorochrome. The emitted light is collected in the fluorescence-3 (FL3) channel. PerCP-Cy5.5 is recommended for use with stream-in-air flow cytometers. APC-Cy7
Fluorochrome Absorption and Emission
. Using a 650 nm longpass filter will give optimum detection for this fluorochrome. The emitted light is collected in the fluorescence-3 (FL3) channel. PerCP-Cy5.5 is recommended for use with stream-in-air flow cytometers. APC-Cy7
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