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- bs-2975R-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-2975R-Cy7 |
| 英文名称 | Noggin Rabbit pAb, Cy7 conjugated |
| 中文名称 | Cy7标记的指(趾)关节粘连NOG蛋白抗体 |
| 英文别名 | NOG; SYM 1; SYM1; Symphalangism 1(proximal); Synostoses(multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN. |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Noggin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Embryogenesis > Morphogens Developmental Biology > Lineage specification > Ectoderm Stem Cells > Lineage Markers > Ectoderm Stem Cells > Signaling Pathways > TGF beta > Secreted |
| 亚基 | Homodimer. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the noggin family. |
| 功能 | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:100-500} |
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Noggin Rabbit pAb, Cy7 conjugated(bs-2975R-Cy7)-100ul
￥2980
